ethylene diglycol monoethyl ether
2-(2-Ethoxyethoxy)ethanol
CAS: 111-90-0
Molecular Formula: C6H14O3
ethylene diglycol monoethyl ether - Names and Identifiers
ethylene diglycol monoethyl ether - Physico-chemical Properties
| Molecular Formula | C6H14O3 |
| Molar Mass | 134.17 |
| Density | 0.999g/mLat 25°C(lit.) |
| Melting Point | -80 °C |
| Boling Point | 202°C(lit.) |
| Flash Point | 205°F |
| Water Solubility | Miscible |
| Solubility | It is miscible in acetone, benzene, chloroform, ethanol and ether. |
| Vapor Presure | 0.12 mm Hg ( 20 °C) |
| Vapor Density | 4.63 (vs air) |
| Appearance | Colorless transparent liquid |
| Color | Clear colorless |
| Odor | Weakly fruity; mild and characteristic. |
| Merck | 14,1800 |
| BRN | 1736441 |
| pKa | 14.37±0.10(Predicted) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Note wide explosion limits. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic. |
| Sensitive | Hygroscopic |
| Explosive Limit | 1.8-12.2%(V) |
| Refractive Index | n20/D 1.427(lit.) |
| MDL | MFCD00002872 |
| Physical and Chemical Properties | Properties of colorless, stable water absorption liquid, flammable. There is a moderate pleasant smell, slightly sticky. The solubility is miscible with water, acetone, benzene, chloroform, ethanol, diethyl ether, pyridine, etc. |
| Use | Mainly used for mutual solvent in paint and ink |
ethylene diglycol monoethyl ether - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R20 - Harmful by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| RTECS | KK8750000 |
| TSCA | Yes |
| HS Code | 29094400 |
| Toxicity | LD50 orally in rats: 8.69 g/kg (Smyth, Carpenter) |
ethylene diglycol monoethyl ether - Upstream Downstream Industry
| Raw Materials | Ethylene Oxide Ethyl Alcohol |
ethylene diglycol monoethyl ether - Reference
| Reference Show more | 1. Hu Chunli, Yang Beibei, Zhang Linjie, et al. Preparation and Quality Control of Lutein Self-microemulsion [J]. Today's Pharmaceutical 2019(9). 2. Wu, JY., Cai, JX., Li, YJ. et al. 3,5,4 '-Trimethoxy-trans-stilbene loaded microemulsion for cutaneous melanoma therapy by transdermal drug delivery. Drug Deliv. and Transl. Res. 11, 169-181 (2021). https://doi.org/10.1007/s13346-020-00757-w 3. [IF = 4.617] Wu Jun-Yong et al."3,5,4'-Trimethoxy-trans-stilbene loaded microemulsion for cutaneous melanoma therapy by transdermal drug delivery." Drug Deliv Transl Re. 2021 Feb;11(1):169-181 |
ethylene diglycol monoethyl ether - Nature
Open Data Verified Data
colorless, water-absorbent stable liquid. Flammable. There is a moderate pleasant smell. Slightly sticky. The relative density was 0. 9898. Boiling point 202.7 C (195 C). Vapor pressure (20 °c)<130Pa. Melting Point -78 °c (vitreous)(-25 °c). Viscosity (20 deg C) 4.5mPa.s. Refractive index 1. 4273 (4300). Molar heat of vaporization 47. lOkj/mol. Flash point (Open Cup) 96.1 °c. With water, acetone, benzene, chloroform, ethanol, ether, pyridine and other miscible.
Last Update：2025-06-10 22:55:16
ethylene diglycol monoethyl ether - Preparation Method
Open Data Verified Data
- in the ethylene oxide method, anhydrous ethanol and boron trifluoride-diethyl ether solution were added to the reactor, and then ethylene oxide was added. When the reaction temperature rose to 45 °c, the reaction temperature was controlled to below 70 °c. After completion of the reaction, the reaction mixture was neutralized and distilled under reduced pressure to collect a fraction of 90 ° C. (0.1 MPa) or less to obtain a finished product.
- The diethylene glycol method is obtained by reacting diethylene glycol and diethyl sulfate.
Last Update：2022-01-01 10:16:05
ethylene diglycol monoethyl ether - Introduction
Slightly fragrant. Easy to absorb moisture. Micro-stickiness. It can be miscible with acetone, benzene, chloroform, pyridine, ethanol, ether, water, etc. The median lethal dose (rat, oral) was 8.69 g/kg. It's irritating.
Last Update：2022-10-16 17:12:04
ethylene diglycol monoethyl ether - Application
Open Data Verified Data
can be used as cellulose, resin, gum, paint, paint and other solvents, printing ink solvent, mineral oil-soap and mineral oil-vulcanized oil mixture of mutual solvent, non-paint colorant, fiber printing agents, varnishes and paint diluents.
Last Update：2025-08-19 16:24:40
ethylene diglycol monoethyl ether - Safety
Open Data Verified Data
has inhibitory effect on the central nervous system. Rat oral LD50 8690mg/kg. Avoid long-term contact with the skin. Operators should wear anti-virus masks to avoid long-term inhalation.
Glass bottle packaging, external use of wooden cases reinforcement, anti-impact, anti-heat, fire. The flammable and toxic substances shall be stored and transported according to the regulations.
Last Update：2022-01-01 10:16:06
ethylene diglycol monoethyl ether - Reference Information
| LogP | -0.54 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | ADI is not specified (FAO/WHO,2001). |
| use | mainly used for mutual solvents in paints and inks carrier solvents. (mainly used in Islamic countries as an ethanol substitute for citrus flavors). This product is a high boiling point solvent. Solvents for cellulose, resins, gums, coatings, printing inks, dyes, mutual solvents for mineral oil-soap and mineral oil-sulfurized oil mixtures, non-paint colorants, fiber printing agents, thinners for varnishes and paints. Used as a solvent, also used for varnish and plastic preparation solvent. Organic synthesis. |
| Production method | 1. Ethylene oxide method First add anhydrous ethanol, boron trifluoride-ether solution to the reactor, and then add ethylene oxide. When the reaction temperature rises to 45 ℃, it is cooled and the reaction temperature is controlled below 70 ℃. After the reaction is completed, the finished product is obtained by neutralization and decompression distillation, and the fraction below 90 ℃(0.1MPa) is collected. 2. Diethylene glycol method is prepared by the reaction of diethylene glycol and diethyl sulfate. It is formed by the condensation of diethylene glycol and 1 molecule of ethanol. |
| category | combustible liquid |
| toxicity classification | low toxicity |
| acute toxicity | oral-rat LD50: 5500 mg/kg; Oral-mouse LD50: 6600 mg/kg |
| stimulation data | skin-rabbit 500 mg/24 hours mild; Eye-rabbit 125 mg mild |
| flammability hazard characteristics | combustible in case of open flame, high temperature and strong oxidant; Combustion emission stimulates smoke |
| storage and transportation characteristics | complete packaging, light loading and unloading; warehouse ventilation, away from open flames, high temperature, separate storage from oxidant |
| fire extinguishing agent | foam, dry powder, carbon dioxide |
| spontaneous combustion temperature | 204°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:47
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View History
ethylene diglycol monoethyl ether
14167-52-3
487-66-1
5806-72-4
92955-92-5
1374516-07-0
Benzenediazonium
53330-19-1
603-41-8
124-11-8
14167-52-3
487-66-1
5806-72-4
92955-92-5
1374516-07-0
Benzenediazonium
53330-19-1
603-41-8
124-11-8
Raw Materials for ethylene diglycol monoethyl ether